Category Archives: news

Stem Cell-Engineered Windpipe for Cancer Patients

From abcnews.com

Doctors in Italy announced they have used patients’ own stem cells to grow trachea tissue that led to seemingly successful transplanted windpipes in two patients diagnosed with trachea cancer.

Is Stem Cell Research Making Progress?

Three distinguished researchers join NPR host Ira Flatow to discuss the latest adult and embryonic stem cell research news, and explain how the research may be used in humans.

Listen to the Story at NPR

Stem Cells Could Change Diabetes Treatment

Doctors say stem cell transplants could help people with Type 1 diabetes live insulin-free lives; the stem cells come from the patient’s own body.

From clipsyndicate.com

Official definition of human embryonic stem cells widened in US

By Dr Philippa Brice, PHGFoundation.org

The official definition of human embryonic stem (HES) cells in US National Institutes of Health (NIH) guidelines is to be broadened from those ‘derived from the inner cell mass of blastocyst stage human embryo’ (ie. from embryos that have reached the blastocyst stage at four or five days old, 70-100 cells), to include also those derived from earlier stage embryos.

Dr Lana Skirboll, director of the Office of Science Policy of the NIH, reportedly said: “We are making what I think is a relatively small technical change to the definition of human embryonic stem cells…This changes none of the ethical requirements in the guidelines” (see Reuters news). This move was prompted by an application from a commercial source to list cell lines derived from eight-cell stage embryos, and will make some commercial and academic research programs potentially eligible for government funding.

Derivation of HES cells from a cell taken from an eight-cell stage embryo could possibly allow implantation and normal development of the remaining seven-cell embryo. This is what happens in pre-implantation prenatal diagnosis (PGD); one cell is removed for genetic analysis and, if healthy, the seven-cell embryo is implanted and can grow into a normal fetus.

A ‘huge leap forward’ for stem cell research

From usatoday.com

Scientists at the Stanford University School of Medicine may have taken the controversy out of the entire field of stem cell research.

In a paper published online today in the journal Nature, they report that they were able to transform mouse skin cells directly into functioning nerve cells without needing to go through a stem cell stage first.

As they say in their paper, this “could have important implications for studies of neural development, neurological disease modeling and regenerative medicine.”

Click link above for complete article.

International Stem Cell Corporation Progresses towards Establishment of the Industry’s First Universal Stem Cell Bank, UniStemCell™

OCEANSIDE, Calif.–(BUSINESS WIRE)–International Stem Cell Corporation (OTCBB: ISCO), www.internationalstemcell.com, announced today that it has signed up the first two in vitro fertilization (IVF) clinics and engaged an experienced pharmaceutical industry executive to lead the establishment of the company’s universal stem cell bank, UniStemCell™. International Stem Cell Corporation has made breakthrough stem cell discoveries that result in unique advantages over the only two other proven methods of making human pluripotent stem cells. In particular, for the first time in industry history, this will enable the establishment of a bank containing a manageable number of stem cell lines that will be immunological matches for large patient populations of different ethnic origin.

“By combining the proven oocyte retrieval experience and clinical excellence of California Center for Reproductive Medicine and Acacio Fertility Center with the pharmaceutical and operational experience of Dr. Craw, International Stem Cell Corporation is well positioned to generate the world’s first cGMP quality hpSC lines in 2010.”

The company uses unfertilized eggs (oocytes) to create human “parthenogenic” stem cells (hpSCs). Like embryonic stem cells (ESCs), hpSCs are pluripotent (i.e. have the capacity to become almost any cell type in the body), yet avoid ethical issues associated with use or destruction of viable human embryos. Unlike induced pluripotent stem cells (iPSs), hpSCs do not involve extensive gene manipulation, which may have unknown biological impact. Unlike both ESCs and iPSs, hpSCs can be created in a homozygous form such that each line will be an immunological match for millions of patients.

International Stem Cell Corporation has partnered with two IVF clinics in Southern California, California Center for Reproductive Medicine under the leadership of Dr. Lori Arnold and Acacio Fertility Center under the leadership of Dr. Brian Acacio. Both clinics provide exceptional clinical care for egg donors and IVF patients, not only regionally but across the US and abroad. California Center for Reproductive Medicine and Acacio Fertility Center provide a US source of oocytes under full regulatory and medical oversight that allow for the creation of the first clinical grade hpSC lines anywhere in the world. Dr. Acacio says: “We look forward to participating in this important research with the ultimate goal of each egg donation not only helping a single couple but millions of people with degenerative diseases.” Dr. Arnold says: “While we provide world-class care for our IVF patients, we are excited to add our clinical expertise and join International Stem Cell Corporation in this medical frontier of regenerative medicine.”

Click here for complete article.

Neuralstem Announces First Patient Treated in ALS Stem Cell Trial

ROCKVILLE, Md., Jan. 21 /PRNewswire-FirstCall/ — Neuralstem, Inc. (NYSE Amex: CUR) announced that the first ALS patient was treated with its spinal cord stem cells yesterday at the Emory ALS Center at Emory University, in Atlanta, GA.  A total of up to 18 patients is planned to be treated in this first U.S. clinical trial to evaluate human neural stem cells for the treatment of ALS (Amyotrophic Lateral Sclerosis, or Lou Gehrig’s disease).  ALS affects roughly 30,000 people in the U.S., with about 5,600 new diagnoses per year, according to the ALS Association.

“The treatment of the first patient with our spinal cord stem cells represents a significant milestone for the Company,” said Neuralstem President and CEO, Richard Garr.

Click here for complete article.

First Successful Use of Expanded Umbilical-Cord Blood Units to Treat Leukemia

ScienceDaily (Jan. 18, 2010) — Scientists at Fred Hutchinson Cancer Research Center have cleared a major technical hurdle to making umbilical-cord-blood transplants a more widely-used method for treating leukemia and other blood cancers.

Click link for more.

Primetime Special on Cord Blood Stem Cell Therapy

Two cerebral palsy patients and CBR clients who are experiencing positive results after undergoing reinfusion of their own cord blood stem cells were featured on the NBC San Francisco Bay Area show Health Matters: Stem Cell Therapy Today & Tomorrow.

Stem Cells: Developing New Cures

New York Stem Cell Foundation (NYSCF) has helped create a video on stem cell research currently playing in the Hall of Human Origins at the American Museum of Natural History in New York. It portrays the promise of stem cell therapies for human disease and demonstrates the potential of the research to create opportunities for studying disease fundamentals.

Stem Cells: Developing New Cures from NYSCF on Vimeo.