Category Archives: video

High hopes for space grown stem cells

Researchers at the Mayo Clinic are preparing to test their theory that stem cells grow faster in microgravity. With a grant from an organisation that promotes research aboard the International Space Station, Dr Abba Zubair will send a batch of cells into space where he believes the future of human tissue generation with stem cells may lie. Ben Gruber reports.

Video provided by Reuters

Stem cell power unleashed after 30 minute dip in acid

The revolutionary discovery that any cell can be rewound to a pre-embryonic state remarkably easily could usher in new therapies and cloning techniques

Click here for complete article.

A Brief History of Stem Cells

A timeline spanning 60 years of stem cell research.
Reporting by Kevin Mayer/ Video by Sunya Bhutta
From GEN Publishing

Stem Cells, and Blood Cells, and Blood Counts, Oh My!

University of California, San Francisco, Osher Center for Integrative Medicine presents Mini Medical School for the Public

FDA approves Phase II of stem cell trial for ALS led by U-M’s Dr. Eva Feldman

ANN ARBOR, Mich. — For nearly two years, University of Michigan neurologist Eva Feldman, M.D., Ph.D. has led the nation’s first clinical trial of stem cell injections in patients with the deadly degenerative disease known as amyotrophic lateral sclerosis, often called ALS or Lou Gehrig’s disease.

Now, a new approval from the U.S. Food and Drug Administration paves the way for U-M to become the second site in the trial, pending approval of the U-M Institutional Review Board. To date, the first phase of the trial has taken place at Emory University, with Feldman serving as principal investigator.

The FDA approval of a Phase II trial was announced today by Neuralstem, the company whose product the trial is testing. The Phase II trial will continue to evaluate the safety of the stem cell injections, delivered directly into patients’ spinal cords in escalating doses of up to 400,000 cells per injection, with a maximum of 40 injections. It will also assess any signs that the injections might be impacting patients’ ALS symptoms or progression.

Feldman serves as an unpaid consultant to the company, and has led the analysis of results from the Phase I trial. In data presented last year, spinal cord injections of up to 100,000 cells were delivered safely and tolerated well — with possible signs that in one subgroup of participants, ALS progression may have been interrupted.

“In Phase II, we’ll be injecting stem cells into the upper part of the spinal cord, and our goal is to continue to assess whether this approach is safe, and to look at whether this approach offers some benefit to our patients. We are very pleased at the potential to bring this trial to the University of Michigan, where the initial research behind this technology was done — as well as having it continue at Emory,” says Feldman, the Russell N. DeJong Professor of Neurology at the U-M Medical School, research director of U-M’s ALS Clinic, and director of U-M’s A. Alfred Taubman Medical Research Institute. The neurosurgeon for the trial is Parag Patil, M.D, Ph.D.

The approach uses injections of stem cells delivered during an operation performed by a neurosurgeon. The first phase of the trial involved 15 patients; specific plans for Phase II are still being made but information will be available at neuralstem.com.

If the U-M site team receives IRB approval to recruit local participants, more information will be available at uofmhealth.org. The study at U-M will be funded by the ALS Association, the National Institutes of Health and Neuralstem.

Parkinson’s Disease Research – Ask the Stem Cell Expert, Dr. Xianmin Zeng

Dr. Xianmin Zeng, associate professor at the Buck Institute for Research on Aging answers your questions about Parkinson’s disease and stem cell research. Zeng has a CIRM research grant to develop a stem cell treatment for Parkinson’s disease.

Parkinson’s disease is a neurodegenerative disorder, which leads to tremors, slowness in movement, impaired balance, and stiffness. There is no cure for Parkinson’s. And although drugs can help reduce symptoms, they eventually lose their effectiveness. Zeng has developed methods for transforming those stem cells into dopamine-producing nerve cells, the same cells that are lost in Parkinson’s disease. The hope is that by transplanting these cells into the brain, they will replace the lost cells and restore function in the brain.

For more information about CIRM-funded stem cell research related to Parkinson’s research, see fact sheet.

Living with Multiple Sclerosis, Hoping for a Stem Cell Therapy

For complete text article see California Institute for Regenerative Medicine

Scientists Create Stem Cells From Urine

Some scientists from China used an unlikely item to make stem cells and it could change the way people think about and treat stem cell research.

According to Reuters, A stem cell biologist and his team have found some success while trying to convert kidney cells found in urine into stem cells. They were using a retrovirus to reprogram the cells, but the stem cells they created were high-risk for tumors. Now they are using vectors, “a type of DNA molecule useful in transporting genetic information.”

Pei Duanqing, Director of the Guangzhou Institutes of Biomedicine and Health, told Reuters that this breakthrough could put the controversy over embryonic stem cell research to rest and give researchers plenty of stem cells to work with in the future.

“It’s an unlimited sources of cells. It’s non-invasive, and the whole procedure is more pleasant than having to take skin biopsies or pluck needles into people,” explained Duanging.

The stem cells formed in a culture in 12 days and quickly transformed into neural cells. After being injected into the brains of newborn rats, there have been no signs of mutations or tumors.

The team continues to make tweaks to their method but have high hopes for the procedure.

Prostate Tissue Stem Cells and Cancer Progression

Lecture by Owen Witte, MD at David H. Koch Institute for Integrative Cancer Research

Deaf gerbils ‘hear again’ after stem cell cure

UK researchers say they have taken a huge step forward in treating deafness after stem cells were used to restore hearing in animals for the first time.

Hearing partially improved when nerves in the ear, which pass sounds into the brain, were rebuilt in gerbils – a UK study in the journal Nature reports.

Getting the same improvement in people would be a shift from being unable to hear traffic to hearing a conversation. However, treating humans is still a distant prospect.

Read more from BBCNews – Deaf ‘hear again’ with stem cells