Tag Archives: AIDS

HIV/AIDS: Progress and Promise in Stem Cell Research

CIRM has funded two HIV/AIDS Disease Teams led by scientists at UCLA and the City of Hope who are focused on stem cell transplant strategies that promise a long lasting resistance to HIV. Antiretroviral therapy provides life-saving medicine to HIV-infected people but it is not a cure. Long-term exposure to the drugs and the virus itself shorten a person’s life, even if they don’t develop AIDS. Both disease teams have a goal of getting to clinical trials within four years. For more info, go to: www.cirm.ca.gov/HIV/AIDS_facts

Stem Cells Cut AIDS Virus in Patient, Ending Need for Drugs

A German AIDS patient was able to stop drugs he had been taking for 10 years after getting a transplant of stem cells from a donor with a rare gene variant known to resist the deadly disease. The transplant also cured his leukemia, researchers reported.

The stem cell donor was among the 1 percent of Caucasians who have the variant gene that lacks a section known as CCR5 that helps the AIDS virus enter a cell, according to a report today in the New England Journal of Medicine. Doctors in Berlin hoped that putting the donor’s stem cells in the patient would rebuild his immune system and blood cells so they would lack the CCR5 piece.

The results of the experiment may point researchers to a new way of controlling the AIDS virus HIV that doesn’t force patients to take drugs for the rest of their lives. Scientists will now intensify their search for therapies that achieve the same effect, predicted Jay Levy, a University of California, San Francisco, AIDS researcher.

“I think this article is going to stimulate a lot of companies to put more emphasis on gene therapy,” Levy said yesterday in a telephone interview. He wasn’t involved in the research and wrote an editorial published today that accompanied the study.

One such trial sponsored by Sangamo Biosciences of Richmond, California, recently began at the University of Pennsylvania. It will test a gene therapy that aims to modify the immune cells in 12 patients infected with HIV so they lack the CCR5 receptor.

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A Stem Cell Treatment ‘against AIDS’

From Hindu.com

Scientists claim to have achieved a major breakthrough in the fight against AIDS with a new stem cell treatment which “protects the immune system from HIV that causes the disease”.

According to them, the pioneering technique involves isolating three genes which curb the spread of HIV inside the body, introducing them into human stem cells in a lab and then transplanting the stem cells into a patient’s bone marrow.

“What we are doing is genetically modifying a fraction of the patient’s stem cells with genes that target three diffe -rent aspects of HIV that allow it to get in the immune cells and replicate.

“When those stem cells are transplanted into patients, they create mature immune cells that circulate in the patient and protect against HIV,” ‘The Daily Telegraph’ quoted David DiGiusto of City of Hope Medical Centre in California, where the research was carried out, as saying.

In the first human trial, the scientists transplanted anti-HIV stem cells into five AIDS patients undergoing bone- marrow replacement as part of treatment for a form of cancer known as lymphoma.

Preliminary results showed that small quantities of the transplanted stem cells were able to grow and produce new white blood cells resistant to HIV resulting in an improvement in the patients’ conditions.

Now, they are planning further research to establish whether the treatment could even rid patients of HIV infection altogether.

“It is still an experimental treatment at the moment, but we hope that eventually we will be able to give AIDS pati- ents one transplant and that would then protect them for life.

We have data to show that the resistant cells are persisting in our lymphoma patients,” DiGiusto said.