Tag Archives: pluripotent

Guidelines for broader stem cell research unveiled

By Saundra Young, CNN.com

The Obama administration released a draft of guidelines for federal funding of human embryonic stem cell research Friday.

Under the new guidelines, federal funding would be allowed only for research using human embryonic stem cells from embryos created solely for reproductive purposes by in vitro fertilization. The embryos would have to no longer be needed for reproduction, and the donors would have to consent to their use for research.

Funding for research using adult stem cells and induced pluripotent stem cells will continue. Funding will not be allowed for stem cells obtained from other sources, including somatic cell nuclear transfer, also known as cloning; in vitro fertilization embryos created specifically for research purposes; and parthenogenesis, the development of an unfertilized egg.

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Video – International Stem Cell Corporation CEO Ken Aldrich

International Stem Cell Corporation is a California company that has developed breakthrough human stem cell lines that promise to eliminate the rejection of transplanted cells by the patients immune system.

International Stem Cell Corporation Chairman and CEO Ken Aldrich

Scientists Create Monkey Stem Cells

(Ivanhoe Newswire) — The successful creation of the first induced pluripotent stem (iPS) cell line from adult monkey skin may have important implications for direct reprogramming capabilities across different species.

Previous studies have shown that induction of four key transcription factors can reprogram adult mouse and human skin cells into iPS cells. Until now, iPS cell creation had not been demonstrated in any other species.

Researchers at Peking University in Beijing, China retrofit viruses to express the four key factors to infect adult monkey skin cells. This technique led to the creation of cells that displayed multiple hallmarks of embryonic stem cells. These cells possessed the ability to develop into multiple types of differentiated cells.

These findings could potentially be useful for the creation of clinically valuable primate models for human disease. The direct reprogramming model may also be a universal strategy for generating iPS cells in other species.

SOURCE: Cell Stem Cell, 2008;3:587-590