Tag Archives: PRKCI

A Prkci Gene Keeps Stem Cells in Check

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THE GENE PRKCI PROMOTES THE GENERATION OF DIFFERENTIATED CELLS (RED). HOWEVER IF PRKCI ACTIVITY IS REDUCED OR ABSENT, NEURAL STEM CELLS (GREEN) ARE PROMOTED. Credit: IN KYOUNG MAH.

When it comes to stem cells, too much of a good thing isn’t wonderful: producing too many new stem cells may lead to cancer; producing too few inhibits the repair and maintenance of the body.

In a paper published in Stem Cell Reports, USC researcher In Kyoung Mah from the lab of Francesca Mariani and colleagues at the University of California, San Diego, (UCSD) describe a key gene in maintaining this critical balance between producing too many and too few stem cells. Called Prkci, the gene influences whether stem cells self-renew to produce more stem cells, or differentiate into more specialized cell types, such as blood or nerves.