Tag Archives: stromal

Stem Cells Show Promise in Extending Transplanted Kidneys’ Survival Time

Can stem cells provide an answer to the perplexing question of how to ensure long-term survival of transplanted kidneys? The results of a new Phase 1 clinical trial say maybe so. Details of the trial, conducted by researchers at Leiden University Medical Center, The Netherlands, are published in the current issue of STEM CELLS Translational Medicine.

Kidney transplants have long been the treatment of choice for many patients with end-stage renal disease, and the short-term results are excellent. But unfortunately, the viability of these kidneys over time has not improved accordingly, often due to fibrosis, which is a scarring of the transplanted organ generally caused by the immune system rejecting it.

The LUMC team, led by Marlies E.J. Reinders, M.D, Ph.D., and Ton J. Rabelink, M.D., Ph.D., decided to test whether stem cells might keep fibrosis in check. They focused on mesenchymal stromal cells, a type of stem cell found throughout the body, including in bone marrow.