Tag Archives: teeth

Scientists use Dental Stem Cells in First Successful Human Transplant

From Benzinga.com

BioEDEN, the world-leader in dental stem cell extraction and storage, is celebrating the first successful human medical trial using stem cells from teeth.

Scientists at The Second University of Naples, Italy have successfully used stem cells taken from dental pulp found in teeth to create new bone tissue and graft it onto a human jaw. The success yields a vast number of medical possibilities for dental stem cells, and for those people who store them for future use.

BioEDEN, based in Daresbury, Cheshire, with laboratory facilities in Austin Texas, and Bangkok Thailand, holds the global patent for the extraction, cryopreservation and storage of dental stem cells for medical use. BioEDEN stores stem cells found in children’s milk teeth, with the hope that one day they will save the donor’s life by being able to repair damaged or diseased tissue.

“For BioEDEN, this achievement is an immaculate demonstration of how vital dental stem cells will come to be in the future of medicine,” said Jim Curtis, Managing Director of BioEDEN. “This is the first time dental stem cell research has moved from the laboratory to human medical trials, and the announcement is truly groundbreaking. It opens up a great deal of medical hope for the future.”

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Replacement teeth grown in mice

Researchers in Japan have successfully grown replacement teeth in mice, according to a report in PNAS journal.

Tissue containing the cells and instructions for building a tooth was transplanted into the jawbones of mice.

They report that these tissue “germs” regularly grew into fully functional teeth with a hardness comparable to that of the natural variety.

The work illustrates a technique that could lead to engineered organ replacements, according to the authors.

They found that nerve fibres were able to grow throughout the teeth and respond to pain stimulation.

The researchers also tracked gene expression in the engineered tooth “germ” with a fluorescent protein.

This revealed that genes that were normally activated in tooth development were also active during growth of the engineered replacement.

The study was led by Etsuko Ikeda from the Tokyo University of Science, Japan.

Stem Cells from Teeth

Scientists may soon grow new teeth in lab

By Stephen Cauchi, Farmonline.com.au

AUSTRALIAN scientists are giving the dentally challenged something to smile about: the prospect of growing new teeth.

Stem cells are being used to grow new tissue around teeth in animals, a first step towards treating dental diseases in humans. The ultimate goal is for teeth to become the first complex organs to be created entirely from stem cells.

“I have no doubt that whole teeth regeneration is going to happen one day,” said Mark Bartold, from the University of Adelaide’s dentistry department.

Should the scientists’ ambitions be realised, whole teeth would be grown in a laboratory using stem cells taken from a patient’s baby or wisdom teeth. These live teeth would be implanted into empty gum sockets, replacing the current method of inserting artificial teeth on metal pins.

The science involves harvesting stem cells from the layer of dental pulp between the tooth’s dentine (the layer immediately underneath the enamel) and the cementum (the layer which covers the tooth’s root).

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